Neural Networks and Bipolar

 

"Bipolar disorder is a common psychiatric condition with significant associated morbidity and mortality. Despite its significance, the neurophysiology and neuropathology of this illness is incompletely understood. Recent advances in neuroimaging techniques have helped to begin clarifying these areas. Specifically, bipolar disorder appears to arise from abnormalities within discrete brain networks (eg, the anterior limbic network). The expression of the symptoms of bipolar disorder does not appear to result from single, localized brain lesions, but rather are emergent properties of dysfunction of these brain networks. As neuroimaging techniques continue to improve, the underlying neural basis of bipolar disorder will be clarified."

Brain Network Dysfunction in Bipolar Disorder | CNS Spectrums | Cambridge Core

"Individuals with bipolar disorder (BP) show abnormalities in the default mode network (DMN), a brain network active at rest and during self-referential cognition. In healthy individuals, the DMN is anti-correlated (strongly negatively correlated) with the task positive network (TPN), a brain network that is active during attention demanding tasks. Mindfulness has been linked to changes in DMN connectivity."

Restoration of default mode network and task positive network anti-correlation associated with mindfulness-based cognitive therapy for bipolar disorder - PubMed (nih.gov)

"Between and within network disruptions across these networks is of interest as over-engagement of one network may result in the manifestation of one subgroup of symptoms, such as emotional instability [3], under-reliance on one network may result in another subgroup of symptoms, such as psychomotor deficits or sensorimotor dysfunction [11]. Mechanistically, in BD it could be expected that a deficit within the FPN and its interaction with SN may account for the symptoms during mania such as disorganised speech, unawareness of mania, inability to downregulate response to perceived positive stimuli, impulsivity and hyperactivity [12]. Meanwhile in MDD, abnormal interactions between the DMN and SN may result in hyper-detection and processing of perceived negative stimuli, poorer memory recall and rumination processes [13]."

Default-mode and fronto-parietal network connectivity during rest distinguishes asymptomatic patients with bipolar disorder and major depressive disorder | Translational Psychiatry (nature.com)